New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences
Identifieur interne : 002341 ( Main/Exploration ); précédent : 002340; suivant : 002342New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences
Auteurs : Leroy E. Hood [États-Unis] ; Gilbert S. Omenn [États-Unis] ; Robert L. Moritz [États-Unis] ; Ruedi Aebersold [Suisse] ; Keith R. Yamamoto [États-Unis] ; Michael Amos [États-Unis] ; Jennie Hunter-Cevera [États-Unis] ; Laurie Locascio [États-Unis]Source :
- PROTEOMICS [ 1615-9853 ] ; 2012-09.
English descriptors
- Teeft :
- Additional peptides, Alzheimer disease, Assay, Battelle technology partnership practice, Biofuel production, Bioinformatics, Biological functions, Biological mechanisms, Biological networks, Biological systems, Biology, Biotechnology, Biotechnology sectors, Bold advances, Budget synergies, Cell biology, Cell lines, Click chemistry, Complex mixtures, Computational sciences, Craig venter institute, Critical need, Disease phenotypes, Disease processes, Dynamic range, Economic activity, Economic impact, Effective drugs, Electron transfer dissociation, Environmental exposures, European bioinformatics institute, External stimuli, Fred hutchinson cancer research center, Functional consequences, Gaithersburg workshop, Gene regulation, Genome, Genome project, Genomic, Genomic revolution, Genomics, Gmbh, Grand challenge, Grand challenges, Greater sensitivity, Human genome project, Human protein atlas, Human proteome, Human proteome project, Individual patients, International endeavor, Kgaa, Knowledge base, Large multiplier, Life sciences, Life technologies, Major components, Many types, Michael amos, Microbial communities, Model organisms, Molecular machines, National academies press, National bioeconomy blueprint, National cancer institute, National institute, National research council, National science, National security, Nist, Nucleic acids, Omics, Omics data, Other proteins, Parts list, Peptide, Predictive models, Protein, Protein epitope signature, Protein functions, Protein interactions, Protein molecules, Proteome, Proteomics, Proteomics data, Proteomics technologies, Reagent, Research resources, Research triangle park, Silico protein, Single cells, Sound waves, Systems approach, Systems biology, Technology council, Technology platforms, Technology policy, Verlag, Verlag gmbh, Weinheim, Weinheim proteomics, White house, White paper, Workshop participants.
Abstract
This White Paper sets out a Life Sciences Grand Challenge for Proteomics Technologies to enhance our understanding of complex biological systems, link genomes with phenotypes, and bring broad benefits to the biosciences and the US economy. The paper is based on a workshop hosted by the National Institute of Standards and Technology (NIST) in Gaithersburg, MD, 14–15 February 2011, with participants from many federal R&D agencies and research communities, under the aegis of the US National Science and Technology Council (NSTC). Opportunities are identified for a coordinated R&D effort to achieve major technology‐based goals and address societal challenges in health, agriculture, nutrition, energy, environment, national security, and economic development.
Url:
DOI: 10.1002/pmic.201270086
Affiliations:
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impact</term><term>Effective drugs</term><term>Electron transfer dissociation</term><term>Environmental exposures</term><term>European bioinformatics institute</term><term>External stimuli</term><term>Fred hutchinson cancer research center</term><term>Functional consequences</term><term>Gaithersburg workshop</term><term>Gene regulation</term><term>Genome</term><term>Genome project</term><term>Genomic</term><term>Genomic revolution</term><term>Genomics</term><term>Gmbh</term><term>Grand challenge</term><term>Grand challenges</term><term>Greater sensitivity</term><term>Human genome project</term><term>Human protein atlas</term><term>Human proteome</term><term>Human proteome project</term><term>Individual patients</term><term>International endeavor</term><term>Kgaa</term><term>Knowledge base</term><term>Large multiplier</term><term>Life sciences</term><term>Life technologies</term><term>Major components</term><term>Many types</term><term>Michael amos</term><term>Microbial communities</term><term>Model organisms</term><term>Molecular machines</term><term>National academies press</term><term>National bioeconomy blueprint</term><term>National cancer institute</term><term>National institute</term><term>National research council</term><term>National science</term><term>National security</term><term>Nist</term><term>Nucleic acids</term><term>Omics</term><term>Omics data</term><term>Other proteins</term><term>Parts list</term><term>Peptide</term><term>Predictive models</term><term>Protein</term><term>Protein epitope signature</term><term>Protein functions</term><term>Protein interactions</term><term>Protein molecules</term><term>Proteome</term><term>Proteomics</term><term>Proteomics data</term><term>Proteomics technologies</term><term>Reagent</term><term>Research resources</term><term>Research triangle park</term><term>Silico protein</term><term>Single cells</term><term>Sound waves</term><term>Systems approach</term><term>Systems biology</term><term>Technology council</term><term>Technology platforms</term><term>Technology policy</term><term>Verlag</term><term>Verlag gmbh</term><term>Weinheim</term><term>Weinheim proteomics</term><term>White house</term><term>White paper</term><term>Workshop participants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">This White Paper sets out a Life Sciences Grand Challenge for Proteomics Technologies to enhance our understanding of complex biological systems, link genomes with phenotypes, and bring broad benefits to the biosciences and the US economy. The paper is based on a workshop hosted by the National Institute of Standards and Technology (NIST) in Gaithersburg, MD, 14–15 February 2011, with participants from many federal R&D agencies and research communities, under the aegis of the US National Science and Technology Council (NSTC). Opportunities are identified for a coordinated R&D effort to achieve major technology‐based goals and address societal challenges in health, agriculture, nutrition, energy, environment, national security, and economic development.</div></front></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Hood, Leroy E" sort="Hood, Leroy E" uniqKey="Hood L" first="Leroy E." last="Hood">Leroy E. 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